QIAGEN Ingenuity Pathway Analysis (IPA): Deep-dive trainings – All Regions – Nov.QIAGEN OmicSoft – Powerful cloud-enabled ‘omics GUI, complete NGS analysis workflows and unparalleled curated content for immediate exploration.Human Somatic Mutation Database (HSMD) – A new somatic database developed by QIAGEN that contains extensive genomic content relevant to solid tumors and hematological malignancies.QIAGEN IPA – Powerful tools to uncover the significance of data and identify new targets or candidate biomarkers within the context of biological systems.Introducing QCI Interpret One, clinical decision support software with professional i. QCI Interpret One – Oncology variant interpretation just got more precise.Catalogue of Somatic Mutations in Cancer (COSMIC) – Explore the impact of somatic mutations in human cancer with the world’s largest and most comprehensive resource.Pharmaceutical Development Bioinformatic Services.Clinical Analysis and Interpretation Services.QIAGEN Discovery Bioinformatics Services.QIAGEN CLC Genomics Workbench – QIAGEN CLC Genomics Workbench is a powerful solution that works for everyone, no matter the workflow.Human Gene Mutations Database (HGMD) – Solve more cases faster, with data you can trust using HGMD Professional, the gold standard for identifying inherited disease-causing mutati.Clinical QKB (Clinical QIAGEN Knowledge Base).COSMIC (Catalogue of Somatic Mutations in Cancer).QIAGEN CLC Genomics Workbench (Desktop).Learn more about its role in oncogenesis and ac. Know your biomarkers: PRKD1 linked to head and neck cancer? – A new cancer gene, PRKD1, has been identified as defining a subset of head and neck cancers.Stop looking for a needle in a haystack – Easily accelerate biomarker and target discovery by exploring and interpreting your data with intuitive, visual biomarker identification too.Single-Cell Genomic Solutions – Explore our powerful solutions for the analysis and interpretation of single-cell gene expression analysis and genomics.Pharmaceutical Development – Whether searching for clinically applicable biomarkers, designing a new companion diagnostic (CDx), or honing your study accrual and go-to-m.Research & Discovery – Powerful digital insights to help you innovate, integrate and translate scientific results into impactful discoveries.Based on these findings, we suggest that the locus designation vif be used to denote all lentivirus ORFs previously called vif, Q, or sor. The SL(I/V)X4YX9Y motif was found only in primate lentiviruses and in bovine immunodeficiency-like virus. SLQXLA was present in 34 of 38 lentiviruses examined, while the remaining four lentiviruses had one (three viruses) or two (one virus) substitutions in this motif (of five total substitutions, three were conservative changes). A search for local sequence similarity revealed that a unifying feature of predicted lentivirus Vif proteins is the presence of at least one of two short, highly conserved sequence motifs, SL(I/V)X4YX9Y and SLQXLA. The Vif proteins of closely related lentiviruses are highly conserved (HIV-1HXB2:HIV-1mn = 91% identity), while those of more distantly related lentirviruses have diverged significantly (HIV-1HXB2:simian immunodeficiency virusmax = 30% identity). The predicted Vif protein sequences from 38 lentiviruses were analyzed for the presence of global and local sequence similarity. Among the lentiviruses, only equine infectious anemia virus lacks a vif ORF. In HIV-1 and other lentiviruses, the vif (viral infectivity factor) open reading frame (ORF) (also termed sor or Q in some lentivirus genomes) is located in the central region, overlapping the 3' end of the pol ORF, but in a different reading frame. The nonstructural/regulatory genes of human immunodeficiency virus type 1 (HIV-1) and other lentiviruses are believed to play an important role in the replication and pathogenesis of these viruses.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |